Sertraline in the treatment of major depression following mild traumatic brain injury.
نویسندگان
چکیده
An 8-week, nonrandomized, single-blind, placebo run-in trial of sertraline was conducted on 15 patients diagnosed with major depression between 3 and 24 months after a mild traumatic brain injury. On the Hamilton Rating Scale for Depression, 13 (87%) had a decrease in score of > or = 50% ("response"), and 10 (67%) achieved a score of < or = 7 ("remission") by week 8 of sertraline. There was statistically significant improvement in psychological distress, anger and aggression, functioning, and postconcussive symptoms with treatment.
منابع مشابه
The clinical significance of major depression following mild traumatic brain injury.
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عنوان ژورنال:
- The Journal of neuropsychiatry and clinical neurosciences
دوره 12 2 شماره
صفحات -
تاریخ انتشار 2000